Transfus Apher Sci 2013 Jul 6

The positive impact of regular exercise program on stem cell mobilization prior to autologous stem cell transplantation.

Keser I, Suyani E, Aki SZ, Gulsan Turkoz Sucak A.
Department of Physiotherapy and Rehabilitation, Gazi University Faculty of Health Sciences, Ankara, Turkey. Electronic address: ilkekeser@yahoo.com.

Abstract

AIM:

The present study was planned to determine the effects of regular exercise program on hematopoietic stem cell (HSC) mobilization prior to autologous stem cell transplantation.

METHOD:

Twenty-two consecutive patients were enrolled in the study. A regular 20min exercise program was administered to the patients. The hematopoietic stem cell mobilization outcome, number of Granulocyte Colony-Stimulating Factor (G-CSF) and aphaeresis application days were compared with 20 case-matched controls who did not receive exercise program during HSC mobilization.

RESULTS:

The median number of CD34⁺ stem cells collected in the exercise and control groups were 8.15×10⁶/kg (range: 2.85-33.06×10⁶/kg) and 7.3×10⁶/kg (range: 1.78-25.9×10⁶/kg), respectively (p=0.696). G-CSF was administered for a median of 8days (range, 5-10) in the exercise group and 8days (range, 5-12) in the control group (p=0.848). The median apheresis duration was 1day (range, 1-3) in both exercise and control groups (p=0.226).

CONCLUSION:

Exercise seems to have a positive impact on stem cell mobilization though without statistical significance.