In this case, we report a 40 year old women, a healthy donor for her sister who has aplastic anemia, who had sharp left upper abdominal pain on the forth mobilization day. The diagnosis at CT scan was splenic rupture; irregular intrasplenic low-attenuation areas consistent with ruptured spleen and perisplenic high density fluid. Her bidimensional spleen size was 16×6 cm.
She was followed conservatively. One month later the CT scan signs of rupture disappeared.
We must pay attention to this rare but serious adverse event during filgrastim use.
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