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Metastatic Pulmonary Calcinosis and Leukocytoclastic Vasculitis in a Patient with Multiple Myeloma
Both leukocytoclastic vasculitis and metastatic pulmonary calcification are conditions that rarely occur during the course of multiple myeloma. We present a multiple myeloma patient that had severe dyspnea due to metastatic pulmonary calcinosis, and ulceronecrotic skin lesions caused by leukocytoclastic vasculitis. After 3 courses of standarddose chemotherapy all skin and pulmonary lesions disappeared. Autologous peripheral stem cell transplantation was performed and during 1 year of follow-up the patient was in complete remission; after 1 year, laboratory test results indicated disease relapse. Although the patient was treated with bortezomib and dexamethasone, the disease progressed. Non-myeloablative allogeneic stem cell transplantation was performed, but despite of all treatment the patient died due to disease progression.

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Authors: Seçkin Çağırgan, Nur Soyer, Filiz Vural, Güray Saydam, Ilgın Yıldırım Şimşir, Ayhan Dönmez, Taner Akalın, Selen Biçeroğlu, Murat Tombuloğlu

Keywords: Multipl myelom, Metastatik kalsifikasyon, Lökositoklastik vaskülit

  • Year: 2012
  • Number: 4
  • Referance No: 23600

  • Figure 3: Leukocytoclastic vasculitis with widespread fibrin thromboses in small vessels (H&E, 200x).
  • Figure 1: Bilateral pneumofibrotic changes in the chest X ray.
  • Figure 2: Chest CT: bilateral diffuse interstitial changes with fibrotic alterations in the lower parts of the lungs.

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