Atlas of Hematology

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Ertugrul Cagri Bolek, Gursel Gunes, Umit Yavuz Malkan, Tuncay Aslan, Sezgin Etgul, Okan Yayar / Hacettepe University School of Medicine, Hematology
Pappenheimer bodies in erythrocytes (myelofibrosis)
The Association Between JAK2V617F Mutation and Bone Marrow Fibrosis at Diagnosis in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms
Figure 1: JAK2V617F-positivity and bone marrow fibrosis
The Association Between JAK2V617F Mutation and Bone Marrow Fibrosis at Diagnosis in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms
Figure 2: JAK2V617F-positivity according to different grades of bone marrow fibrosis
Central retinal artery occlusion as the presenting sign of essential thrombocythemia
Figure 1. The fundus of the right eye at presentation shows the cherry-red spot and attenuated arterioles
Central retinal artery occlusion as the presenting sign of essential thrombocythemia
Figure 2. Coronal oblique computed tomographic angiography of the entire supra-aortic region. The right common carotid artery is occluded 2 cm distal to its origin (arrow). The right internal carotid artery is also occluded; right intracranial carotid circulation is provided by collateral pathways
Complex cytogenetic findings in the bone marrow of a chronic idiopathic myelofibrosis patient
Figure 1. Karyotype of the patient: 46,XY,del(9)(q22q34),t(8;17;21)(q22;q21;q22)
Complex cytogenetic findings in the bone marrow of a chronic idiopathic myelofibrosis patient
Figure 2. a: Metaphase spread of the patient; relevant chromosomes are marked with arrows b: The same metaphase after fluorescence in situ hybridization with Whole Chromosome Probe 8 Spectrum Orange (Vysis, USA); relevant chromosomes are marked with arrows
Complex cytogenetic findings in the bone marrow of a chronic idiopathic myelofibrosis patient
Figure 3. a: Metaphase spread of the patient; relevant chromosomes are marked with arrows b: The same metaphase after fluorescence in situ hybridization with Whole Chromosome Probe 17 Spectrum Orange (Vysis, USA); relevant chromosomes are marked with arrows
Enhanced platelet adhesion in essential thrombocythemia after in vitro activation
Figure 1. Platelet adhesion to albumin (a), collagen (b), fibrinogen (c), and fibronectin (d) was significantly increased by ADP (1 and 10 µmol/L) for both controls and ET-platelets. A dose-response relationship was seen on all surfaces for ET-platelets, but only on albumin and fibronectin for controls. Differences in basal adhesion (solvent) between the three groups were not significant. Data are presented as mean+SD. Filled bars = Controls (n = 11 except for fibronectin where n = 10, age range: 31-63 years), open bars = Age-matched patients (n = 14, age range: 30-66 years), patterned bars = Patients ? 67 years (n = 16, age range: 67-87 years). ns = not significant, **p
Enhanced platelet adhesion in essential thrombocythemia after in vitro activation
Figure 2. The combination of 0.1 µmol/L adrenaline (Adr) and 10 µmol/L LPA increased platelet adhesion synergistically to albumin for both ETplatelets and controls. Data are presented as mean+SD. Filled bars = Controls (n = 11, age range: 31-63 years), open bars = Age-matched patients (n = 14, age range: 30-66 years), patterned bars = Patients ? 67 years (n = 16, age range: 67-87 years). ns = not significant, **p

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