10.07.2009
Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid–based proteasome inhibitors
Encouse B. Golden1, Philip Y. Lam2, Adel Kardosh3, Kevin J. Gaffney4, Enrique Cadenas2, Stan G. Louie5, Nicos A. Petasis4, Thomas C. Chen1,6, and Axel H. Schönthal3
1 Department of Pathology, University of Southern California (USC) Keck School of Medicine (KSOM), Los Angeles; 2 Department of Molecular Pharmacology and Toxicology, USC School of Pharmacy (SoP), Los Angeles; 3 Department of Molecular Microbiology and Immunology, USC KSOM, Los Angeles; 4 Department of Chemistry, USC College of Letters, Arts and Sciences, Los Angeles; 5 Department of Clinical Pharmacy and Pharmaceutical Economics and Policy, USC SoP, Los Angeles; and 6 Department of Neurosurgery, USC KSOM, Los Angeles
The anticancer potency of green tea and its individual components is being intensely investigated, and some cancer patients already self-medicate with this "miracle herb" in hopes of augmenting the anticancer outcome of their chemotherapy. Bortezomib (BZM) is a proteasome inhibitor in clinical use for multiple myeloma. Here, we investigated whether the combination of these compounds would yield increased antitumor efficacy in multiple myeloma and glioblastoma cell lines in vitro and in vivo. Unexpectedly, we discovered that various green tea constituents, in particular (-)-epigallocatechin gallate (EGCG) and other polyphenols with 1,2-benzenediol moieties, effectively prevented tumor cell death induced by BZM in vitro and in vivo. This pronounced antagonistic function of EGCG was evident only with boronic acid–based proteasome inhibitors (BZM, MG-262, PS-IX), but not with several non–boronic acid proteasome inhibitors (MG-132, PS-I, nelfinavir). EGCG directly reacted with BZM and blocked its proteasome inhibitory function; as a consequence, BZM could not trigger endoplasmic reticulum stress or caspase-7 activation, and did not induce tumor cell death. Taken together, our results indicate that green tea polyphenols may have the potential to negate the therapeutic efficacy of BZM and suggest that consumption of green tea products may be contraindicated during cancer therapy with BZM.
Blood, 4 June 2009, Vol. 113, No. 23, pp. 5927-5937
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/113/23/5927
purchase suprax overnight
suprax sale suprax overnight
suprax dose suprax 200 mg
purchase suprax overnight
suprax sale suprax overnight
400 mg suprax suprax 200 mg
purchase suprax overnight
suprax sale suprax overnight
suprax suprax 200 mg
350,000 problem gamblers
teen gambling
gambling council on compulsive gambling of nj, inc.
350,000 problem gamblers
teen gambling
compulsive gambling. council on compulsive gambling of nj, inc.
350,000 problem gamblers
teen gambling
click here council on compulsive gambling of nj, inc.
buy clarithromycin canada
buy biaxin 500mg
clarithromycin buy biaxin canada
buy clarithromycin canada
buy biaxin 500mg
order biaxin buy biaxin canada
buy clarithromycin canada
buy biaxin 500mg
order biaxin buy biaxin canada
buy discount clarithromycin
clarithromycin online
buy biaxin usa cheapest biaxin
buy discount clarithromycin
clarithromycin online
buy biaxin usa cheapest biaxin
buy clarithromycin no prescription
buy cheap biaxin
buy clarithromycin buy generic clarithromycin
buy clarithromycin no prescription
buy cheap biaxin
buy clarithromycin buy generic clarithromycin
buy clarithromycin no prescription
buy cheap biaxin
buy clarithromycin buy generic clarithromycin
buy clarithromycin no prescription
buy cheap biaxin
buy clarithromycin buy generic clarithromycin
where to buy abortion pills online
where can i buy abortion pills
abortion pill buy the abortion pill online
online purchase abortion pill
where can i buy abortion pills
abortion pills order abortion pill online
online purchase abortion pill
where can i buy abortion pills
abortion pills order abortion pill online
online purchase abortion pill
where can i buy abortion pills
abortion pill order abortion pill online
how to order the abortion pill online
abortion pill online purchase
order abortion pill online how to order the abortion pill online
how to order the abortion pill online
abortion pill online purchase
abortion pill how to order the abortion pill online
buy viagra online safe
alternative to viagra
viagra online get viagra
buy viagra online safe
alternative to viagra
viagra kaufen get viagra
buy viagra online safe
alternative to viagra
viagra kaufen get viagra
female uk kamagra
cialis vs kamagra
kamagra order kamagra online
problems with kamagra jelly
buy kamagra jelly in london england
kamagra jelly kamagra jelly side effects
problems with kamagra jelly
buy kamagra jelly in london england
kamagra jelly kamagra jelly side effects
problems with kamagra jelly
buy kamagra jelly in london england
kamagra jelly kamagra jelly side effects
generic amoxil
buy cheap amoxil online uk
amoxicillin amoxil for sale
generic amoxil
buy cheap amoxil online uk
amoxicillin amoxil for sale
generic amoxil
buy cheap amoxil online uk
amoxicillin amoxil for sale
free synthroid sample
women does synthroid work
synthroid synthroid dosage
free synthroid sample
women does synthroid work
synthroid synthroid dosage
women does bisacodyl work
natural bisacodyl alternatives
laxative get bisacodyl online
women does bisacodyl work
natural bisacodyl alternatives
natural laxative get bisacodyl online
women does bisacodyl work
natural bisacodyl alternatives
laxative get bisacodyl online
buy ampicillin online safe
female herbal principen
ampicillin principen for sale
buy ampicillin online safe
female herbal principen
ampicillin principen for sale
buy abortion pill online
pill for abortion online
abortion pill order abortion pill
buy abortion pill online
pill for abortion online
abortion pill order abortion pill
buy abortion pill online
pill for abortion online
abortion pill order abortion pill
buy abortion pill online
pill for abortion online
buy abortion pill order abortion pill
buy clarithromycin australia
discount clarithromycin
clarithromycin cheap clarithromycin
buy clarithromycin australia
discount clarithromycin
clarithromycin cheap clarithromycin
buy clarithromycin australia
discount clarithromycin
clarithromycin cheap clarithromycin
generic cipro
natural ciprofloxacin
ciprofloxacin buy ciprofloxacin online a href
generic cipro
natural ciprofloxacin
ciprofloxacin buy ciprofloxacin online a href
cheap duricef tablets
duricef prescription buy
get Cefadroxil generic Cefadroxil
cheap duricef tablets
duricef prescription buy
cefadroxil generic Cefadroxil
buy vantin
photos cefpodoxime
cefpodoxime cefpodoxime equivalent
buy vantin
photos cefpodoxime
cefpodoxime cefpodoxime equivalent
buy vantin
photos cefpodoxime
cefpodoxime cefpodoxime equivalent
buy ceftin online
generic cefuroxime sale
cefuroxime cheap ceftin
buy ceftin online
generic cefuroxime sale
cefuroxime cheap ceftin
buy ceftin online
generic cefuroxime sale
cefuroxime cheap ceftin
buy ceftin online
generic cefuroxime sale
cefuroxime cheap ceftin
ordering abortion pills to be shipped to house
abortion pill online purchase
abortion pill buy abortion pills online
ordering abortion pills to be shipped to house
abortion pill online purchase
abortion pill buy abortion pills online
ordering abortion pills to be shipped to house
abortion pill online purchase
pill for abortion online buy abortion pills online
buy chloromycetin on the internet
photos chloromycetin
chloramphenicol chloromycetin samples
buy chloromycetin on the internet
photos chloromycetin
chloramphenicol chloromycetin samples
buy abortion pills online
buy abortion pill online
abortion pill ordering abortion pills to be shipped to house
where to buy clavulanate online
alternative to augmentin
augmentin generic augmentin online
where to buy clavulanate online
alternative to augmentin
augmentin generic augmentin online